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Recombinant Murine M-CSF
名称 Recombinant Murine M-CSF
型号
更新时间 2023-09-24
特点 M-CSF是一个有效的造血因子由多种细胞包括淋巴细胞、单核细胞、成纤维细胞、内皮细胞、成肌细胞和成骨细胞。M-CSF临床上用于治疗感染,恶性肿瘤和动脉粥样硬化。它促进骨髓移植后造血恢复。重组小鼠M-CSF是36.4 kDa homodimeric蛋白质包含两个156氨基酸多肽子单元。使用所有无动物生产试剂。}
  • 详细内容

一.产品名称:Recombinant Murine M-CSF/Peprotech M-CSF

二.Catalog Number:AF-315-02

三.Synonyms:Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

四.Description:

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits. Manufactured using all non-animal reagents.

五.AA Sequence:

MKEVSEHCSH MIGNGHLKVL LIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to stimulate the proliferation of murine M-NFS-60 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥1 x 106 units/mg.

九.Cross Reactivity:Mouse, Rat

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