一.产品名称：Recombinant Murine M-CSF/Peprotech M-CSF

二.Catalog Number:AF-315-02

三.Synonyms:Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

四.Description:

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits. Manufactured using all non-animal reagents.

五.AA Sequence:

MKEVSEHCSH MIGNGHLKVL LIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to stimulate the proliferation of murine M-NFS-60 cells. The expected ED₅₀ is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥1 x 10⁶ units/mg.

九.Cross Reactivity:Mouse, Rat